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ACUTE TOXICITY AND ANTINOCICEPTIVE ACTIVITY OF CRUDE ETHANOL EXTRACT OF SECURIDACA LONGEPEDUNCULATA (FRESEN) ROOT BARK IN ALBINO RATS

Abstract

Saidu Ibrahim Ngulde

ABSTRACT The Securidaca longepedunculata crude root bark extract was studied in rats to evaluate its acute toxicity and antinociceptive effects. The LD50 was determined using Lorke’s methods while tail flick, hotplate and formalin test methods were used to evaluate the antinociceptive activities of the extract at doses of 3mg/kg and 6mg/kg intraperitoneally. The result of the LD50 value was 14.14mg/kg. The extract exhibited significant antinociceptive effect at 6mg/kg (P<0.05) as compared to the control in tail flick test and in both phases of formalin test. It was concluded that the crude ethanol extract of S. longepedunculata possessed dose dependent antinociceptive activities but it was a highly toxic extract in rats with intraperitoneal LD50 value of 14.14mg/kg

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