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AN OVERVIEW ON DOCKING STUDIES WITH ALDOSE REDUCTASE INHIBITORS

Abstract

Zeyad Ahmmed Dahan Mohammed, Sayyed Hussain Sajjansab and PK Zubaidha

Molecular modeling methods have become integral part of drug discovery programs as they enable study of complex biological and chemical systems and hence design of lead molecules of therapeutic significance. Over the last few decades, it has been routinely and successfully applied in most pharmaceutical and biotech companies for a large number of applications. The activation of the key enzyme Aldose reductase in polyol pathway under hyperglycemic conditions is responsible for the development of late diabetic complications and it is an important drug target. This review provides an update on the docking strategies employed for screening various synthetic and natural aldose reductase inhibitors and provide an overview of the structural features involved in binding within the active site. The docking results reveal that several active constituents of medicinal plants exhibit remarkable aldose reductase activity and they may serve as lead for the development of novel ALRs of therapeutic significance.

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