EVALUATION OF WOUND HEALING ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM BASILICUM AND AEGLE MARMELOS LEAVES IN MALE ALBINO RATS

Abstract

Renu Solanki* 1 , Vipin Mathur1 , Shiv Kumar Puroh

Wounds are major cause of physical disabilities. Wound healing consists of orderly progression of series of events that establish the integrity of the damaged tissues. Aegle marmelos (Bael) is used for medicinal purposes, including treatment of dyspepsia, inflammation, asthma, hypoglycemia, cancer, hepatitis, diabetes, sinusitis, tuberculosis, diarrhea, dysentery, as astringent, digestive, stomachic etc. Recent pharmacological studies have established various pharmacological properties of Ocimum basilicum (Bantulsi) like anabolic, hypoglycemic, smooth muscle relaxant, cardiac depressant, antifertility, adaptogenic, antifertility, antidiabetic, antimicrobial, antiallergic and immunomodulator properties. The present study was undertaken on ethanolic extract of leaves of Aegle marmelos and Ocimum basilicum on wound healing activity through topical route on excision wound model. The activity was compared with standard drug povidone iodine ointment (5% w/w) respectively. The leaves of Aegle marmelos ethanolic extract was found to have better wound healing effect than ethanolic extract of leaves of Ocimum basilicum on excision wound model. The leaves of Aegle marmelos ethanolic extract also showed faster rate of healing when compared with standard topical application