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FORMULATION AND EVALUATION OF CONTROLLED RELEASE PELLETS OF METOPROLOL SUCCINATE BY EXTRUSION-SPHERONIZATION METHOD

Abstract

Kailas N Tarkase, Sachin P Garje and Akash B Bondre

The objective of this study was to prepare and evaluate controlled release pellets of Metoprolol Succinate by using Extrusion-Spheronization Method. The different formulations were prepared using Eudragit L, Ethyl Cellulose as hydrophobic polymer, MCC PH 101 as a Spheronizing aid and methyl alcohol as a solvent. In vitro drug release study in pH 6.8 phosphate buffer. Stability studies were carried out for a period of 90 days at 40±2 °C and 75±5% RH. The drug content was in the range of 96.09%. The mean particle size of the drug loaded pellets was in the range 96 μm to 1010.21 μm. SEM photographs and calculated sphericity factor confirmed that the prepared formulations were spherical in nature. The compatibility between drug and polymers in the drug loaded pellets was confirmed by DSC and FTIR studies. Stability studies indicated that pellets are stable

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