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FORMULATION AND EVALUATION OF pH INDUCED IN-SITU NASAL GEL FOR BRAIN TARGETING OF LEVODOPA

Abstract

Piyush Jangam and Ambekar Abdul Wahid

Background: Levodopa is used in the treatment of Parkinson. It get absorbed from small intestine, but Levodopa get metabolized in peripheral tissues by L-aromatic amino acid decarboxylase (AAAD) enzyme, which degrades levodopa and thus serves as a significant barrier to the absorption of intact levodopa; only 30% of an orally administered dose reaches the circulation. Methods: In situ nasal gel of levodopa was prepared to increase its bioavailability as well as rapid onset of action. Carbapol 934 was used as the gelling agent to form the gel in the nasal pH. To overcome the problem of mucociliary clearance we used here HPMC K4M as the mucoadhesive polymer. Thus different formulations were prepared by using different combination of the polymers judicially and evaluated them in respect of pH, gelation temperature, mucoadhesive force and permeation of levodopa. Results: From the above study, we observed that the pH sensitive polymer and mucoadhesive polymer used here had distinct effects.

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