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SZ Chemate and Rahul M Anbhule

The purpose of present research work was to develop a Film Forming Emulgel formulation of Terbinafine hydrochloride using carbopol 934 as a gelling agent for topical delivery with the aim to avoid hepatic firstpass metabolism, improve stability of emulsion, reduce dosage regimen and enhance residence time in the treatment of fungal infection. Film Forming Emulgels have emerged as one of the most interesting topical drug delivery systems as it has dual release control i.e. emulsion and gel. The developed emulgels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behavior, drug content, drug release and stability. Commercially available Terbinafine hydrochloride cream was used for comparison. All the prepared emulgels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value. The drug release was found to be higher for optimized formulation as compared to the marketed Terbinafine hydrochloride cream. The highest drug release was observed with T4, where the drug release showed 92.05%. The drug release from all the emulgels were found to follow diffusion-controlled mechanism. Stability studies indicated that the physical appearance, rheological properties, spreadability, drug release in all the prepared emulgels remained unchanged upon storage for 3 months.


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