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FORMULATION AND IN-VITRO EVALUATION OF IRINOTECAN LOADED MUCOADHESIVE MICROSPHERES MADE OF CHITOSAN-ALGINATE MIXTURE BY USING IONOTROPIC GELATION TECHNIQUE

Abstract

Champak Kalita, Abdul Baquee Ahmed

In this study, we prepared irinotecan microparticles using Chitosan and alginate as a polyelectrolyte complex by ionotropic gelation method for sustained release of the drug. Compatibility studies of drug with various excipients were performed by FT-IR and DSC studies between 1:1 physical mixtures of drug and excipients. The developed microspheres were evaluated for particle size, entrapment efficiency, in-vitro drug release and surface morphology by scanning electron microscopy (SEM). The results of FT-IR and DSC studies confirmed the compatibility of the drug with excipients. The average particle size of formulations was found to be 410±12.54µm, the entrapment efficiency of drug in formulation was found to be 84.56±2.150%, and the in-vitro drug release studies of F5 formation in phosphate buffer pH 6.8 showed 87.21±2.514 % release of drug at the end of 8 h. Thus the study concludes development of sustained release micro particular delivery of irinotecan using simple inotropic gelation method.

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