RP-HPLC METHOD FOR THE ESTIMATION OF ACECLOFENAC IN TABLET DOSAGE FORM
Abstract
Jat R.K.1*,R. C. Chhipa 1, S. Sharma 2
A simple, sensitive and precise RP
-
HPLC method was developed for the determination of
aceclofenac
in
tablet dosage form. The RP
-
HPLC separation was achieved on hypersil C18 column (250 mm, 4.6 mm,
5μm) using mobile phase
water:
acetonitrile (55:45
v/v) at flow rate of 1 ml/min at ambient temperature.
Quantification
was achieved with photodi
ode array detection at 277 nm over
the concentration range of 1
-
10
μm/ml. The method was validated statistically and applied successfully for the determination o
f
acecl
ofenac
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