International Journal of Drug Research and Technology

SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE IN BULK AND TABLET DOSAGE FORM

Abstract

Shinde N C, Pawar PY and Balame VD

Simple, precise accurate and economical UV Spectrophotometric methods have been developed and validated for the routine estimation of Metformin hydrochloride and Glimepiride in bulk drug and pharmaceutical preparations. Absorbance maxima method based on measurement of absorption at maximum for Metformin hydrochloride and Glimepiride wavelength. The method validated according to ICH guidelines in respect of precision, accuracy, sensitivity and linearity