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STUDY OF GONADAL HORMONES IN EGYPTIAN FEMALE CHILDREN WITH END STAGE RENAL DISEASE UNDER REGULAR HAEMODIALYSIS IN CORRELATION WITH DIALYSIS DURATION

Abstract

Mohamed A El-Gamasy, Mohamed M Abdelmageed and Mohammed Abd Ellatif Nassar

Background: Estradiol hormone is susceptible to significant pathophysiological alterations in children with End Stage Renal Disease (ESRD) under regular hemodialysis (HD), leading to delayed pubertal maturation. Aim of the work was to evaluate the plasma levels of follicular stimulating hormone (FSH), luteinizing hormone (LH) and estradiol hormone in female children and adolescents with ESRD under HD and its correlation with dialysis duration.

Subjects and Methods: This study was carried out on 40 girls with ESRD under regular HD who were attending the Pediatric Nephrology Unit of Tanta University Hospital at Egypt.Forty age- and sex-matched children were served as controls. Puberty was assessed according to Tanner's classification with measurements of serum FSH, LH to assess hypothalamic pituitary gonadal axis and serum estradiol levels.

Results: There were significantly lower FSH, LH, and estrogen levels in Group I compared with Group II. Mean FSH level was 1.36 ± 0.22 mIU/mL in Group I vs. 2.64 ± 0.81 mIU/mL in Group II with. Mean LH level was 0.11 ± 0.006 mIU/mL in Group I vs. 1.78 ± 1.12 mIU/mL in Group II. Mean estrogen level was 26.69 ± 21.59 pg/mL in Group I vs. 51.03 ± 26.50 pg/mL in Group II.There was significant negative correlations between the dialysis duration and serum FSH,LH and Estradiol levels in patients group.
Conclusions: Female patients with ESRD had delayed puberty secondary to gonadal hormones deficiency including FSH, LH, estrogen with significant negative correlations between them and duration of hemodialysis.

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