GET THE APP

Reach Us +32-466-90-04-51
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal

SYNTHESIS, ANTICONVULSANT, BENZOTRIAZOLOAZEPINES

Abstract

Xia Huang, Rong-Bi Han, Feng-Yu Piao, Tie Chen

A series of novel 3-Substituted-1,3,4,5-Tetrahydro-2H-benzo [b] azepine-2-one Derivatives (4, 5, 7, 10, 12, 5a-j, 8a-e) were synthesized from 1,2,3,4-Tetrahydro-1-naphthalenone. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, MASS spectra and elemental analysis. Their anticonvulsant activity was evaluated the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test. Compound 4 showed the maximum anticonvulsant activity against MES (ED50=26.4, PI =3.2) and against scPTZ (ED50=40.2, PI =2.1). Possible structure–activity relationship is discussed.

PDF

Share this article

paper.io

agar io

wowcappadocia.com cappadocia tours
cappadocia-hotels.com cappadocia hotels
caruscappadocia.com cappadocia hotel
brothersballoon.com cappadocia balloon
balloon-rides.net cappadocia balloon flights

wormax io