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SYNTHESIS, ANTIMICROBIAL AND ANTHELMINTIC ACTIVITY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES

Abstract

Faruk Alam, Biplab Kumer Dey, Kamal Sharma, Arpita Chakraborty, Pallab Kalita

The benzimidazoles are also known as benzoglyoxalines. Benzimidazole derivatives are very useful intermediates or subunits of the development of pharmaceutical or biological interest. Benzimidazole derivatives play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. With the purpose of finding new chemical entities with enhanced antimicrobial activity, series comprises 1 and 2-substituted-5- nitrobenzimidazole derivatives were synthesized. The presence of specific functional group were analyzed by IR spectroscopy. The determination of structure for the synthesized compounds by 1H NMR and mass spectroscopy. Antimicrobial activity against bacteria and fungi was studied. The anthelmintic activity was evaluated on adult Indian earth worm Pheretima posthuma. The results of preliminary biological tests showed that of these compounds showed significant antimicrobial activity and anthelmintic activity.

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