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TASTE MASKING FORMULATION AND EVALUATION OF CIPROFLOXACIN HCL USING ION EXCHANGE RESINS

Abstract

Amarjeet Yadav, Navneet Garud, RK Jat

Some drugs are bitter and unpleasant in taste and taking orally very difficult for children and some adults. Non-compliance can lead to worsening of diseased condition. Numbers of taste masking technologies have been used to address the problem of patient compliance. The purpose of this research was to mask the intensely bitter taste of Ciprofloxacin HCl and to formulate a palatable liquid formulation of the tastemasked drug, by novel Ion Exchange Resin (IER) method to overcome taste problem with traditional system. Taste masking was done by complexing Ciprofloxacin HCl with Tulsion 335, Indion 254 and Indion 414 in different ratios. Formulation containing resinates were tested for drug content, in vitro drug release, taste masking, stability study, and molecular property. The resinates prepared with drug- Indion 254 ratio (1:2) at pH 8, gave maximum drug loading. Suspension containing above resinates showed more than 80% In vitro drug release within 30 min. Prepared formulation also showed good stability and can retain its palatable taste. Thus, the “patient-friendly dosage form” of bitter drugs, especially for pediatric, geriatric, bedridden, and non-cooperative patients, can be successfully formulated using this technology.

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