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Ahmed Shah and Saeid Amini-Nik

Wounds are a disruption to the continuity of cells that is repaired through well-coordinated steps including inflammation, proliferation and extra-cellular matrix (ECM) remodeling. Often these processes are dysregulated, resulting in either impaired wound healing seen in chronic diabetic wounds, or excessive healing seen in hypertrophic scarring. The serotoninergic system is historically known for its action in the central and peripheral nervous systems, but its role in wound healing is recently coming to light. Serotonin (5HT) has an important role in the promotion of wound healing, particularly in the inflammatory and proliferative stages. In this review, we discuss the role of serotonergic agents and serotonin receptor antagonists in wound healing. Moreover, we discuss the potential mechanisms of actions, and the advantages and limitations of these drugs in the treatment of acute wounds, chronic wounds, and hypertrophic scarring. Since the effects of the serotoninergic pathway in the context of wound healing is largely unexplored, we also discuss where future research in the field is warranted.


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