+447897072958UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND QUANTITATIVE ESTIMATION OF GLIPIZIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Abstract
Bikash Ranjan Jena, Suryakanta Swain, Sitty Manohar Babu, Debi Prasad Pradhan and Kothamasu Sasikanth
The present study demonstrates a simple, precise and accurate UV spectrophotometric method development for the quantitative estimation of glipizide in bulk and pharmaceutical dosage forms. The analysis was carried out by using Elico SL 159 UV –Visible spectrophotometer with 1cm matched quartz cells. In this study, the zero order spectrum of glipizide in the presence of phosphate buffer (pH 3.8) is conducted and measured the absorbance at λmax 230 nm. The method was verified by using various validation parameters such as linearity, accuracy, precision. The calibration curve was linear over the concentration range tested (1–50 μg/mL). The accuracy and precision studies were carried out which is less than 2% that indicates good accuracy and precision values. There is no interference of excipients used in the formulation as low % RSD values in the recovery studies. These results indicate that the method shows a practical application as a quality control tool for analysis of the drug in its tablet dosage forms in pharmaceutical industries. The developed method was validated according to ICH-Q1C guidelines and it is applicable for the analysis of bulk drug in its tablet dosage forms.
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