Research Progress of Helpful Medications for Doxorubicin-Prompted Cardiomyopathy

Silvia Sonzini^*
*Correspondence: Silvia Sonzini, Department of Pharmaceutical Sciences, University of Miami School of Medicine, Miami, Florida, USA, Email:

Received: 02-May-2023, Manuscript No. IJDRT-23-106055; Editor assigned: 04-May-2023, Pre QC No. P-106055; Reviewed: 16-May-2023, QC No. Q-106055; Revised: 22-May-2023, Manuscript No. R-106055; Published: 29-May-2023, DOI: 10.37421/2277-1506.2023.12.403

Introduction

Doxorubicin is a chemotherapy drug commonly used in the treatment of various types of cancer. However, its use is associated with the potential risk of cardio toxicity, which can lead to doxorubicin-induced cardiomyopathy. Cardiomyopathy refers to the weakening of the heart muscle, which can result in heart failure and other cardiovascular complications. Researchers have been actively working on finding helpful medications to prevent or mitigate doxorubicininduced cardiomyopathy. Researchers have explored various cardio protective agents to reduce doxorubicin-induced cardio toxicity. These agents aim to protect the heart from the damaging effects of doxorubicin without compromising its anticancer efficacy. Some of the substances being studied include dexrazoxane, a cardio protective agent that can help prevent doxorubicin-induced cardiac damage. Doxorubicin-induced cardiomyopathy is associated with increased oxidative stress, which can damage cardiac cells. Antioxidants, such as coenzyme Q10, vitamin E, and N-acetyl cysteine, have been investigated for their potential to reduce oxidative stress and mitigate doxorubicin-induced cardio toxicity [1].

Description

Researchers are exploring the use of nanotechnology and drug delivery systems to improve the targeted delivery of doxorubicin to cancer cells while minimizing its exposure to the heart. By encapsulating doxorubicin within nanoparticles or liposomes, the drug can be selectively delivered to cancer cells, reducing the potential cardiotoxic effects. Genetic studies have aimed to identify specific genetic markers that can predict an individual's susceptibility to doxorubicin-induced cardiomyopathy. By understanding the genetic factors involved, researchers hope to develop personalized treatment strategies or interventions to reduce the risk or severity of cardio toxicity. Advances in cardiac imaging techniques, such as echocardiography, cardiac MRI, and nuclear imaging, have helped in the early detection and monitoring of cardiac changes in patients undergoing doxorubicin treatment. Additionally, researchers have explored the use of specific biomarkers, such as troponins and Brain Natriuretic Peptide (BNP), as indicators of doxorubicin-induced cardio toxicity [2].

Stem cell therapy holds promise for repairing damaged cardiac tissue caused by doxorubicin-induced cardiomyopathy. Preclinical studies have shown that stem cells, such as mesenchyme stem cells or cardiac progenitor cells, can improve cardiac function and promote tissue repair in animal models. Researchers are also exploring the role of lifestyle interventions in mitigating doxorubicin-induced cardio toxicity. Strategies such as exercise, dietary modifications, and cardio protective lifestyle behaviours may have a positive impact on cardiac health and help reduce the risk of cardiomyopathy. Cardio protective lifestyle refers to a set of behaviours and habits that promote cardiovascular health and reduce the risk of heart disease and related conditions. Adopting a cardio protective lifestyle can have a positive impact on overall heart health, including reducing the risk of cardiomyopathy and other cardiovascular complications [3].

A heart-healthy diet is rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. It emphasizes the consumption of nutrient-dense foods while limiting the intake of saturated and trans fats, added sugars, and sodium. The Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet are two examples of eating patterns associated with cardiovascular health. Engaging in regular physical activity is crucial for cardiovascular health. It helps maintain a healthy weight, improves blood circulation, lowers blood pressure, and reduces the risk of heart disease. Aim for at least 150 minutes of moderateintensity aerobic exercise or 75 minutes of vigorous-intensity exercise each week, along with muscle-strengthening activities at least twice a week. Quitting smoking and avoiding exposure to second-hand smoke are essential for heart health. Smoking is a major risk factor for cardiovascular disease, including cardiomyopathy. Seek support and resources to quit smoking, as it can significantly improve heart health and overall well-being. If you choose to drink alcohol, do so in moderation. Moderate alcohol consumption is defined as up to one drink per day for women and up to two drinks per day for men. Excessive alcohol consumption can increase the risk of heart disease and other health problems [4].

Maintaining a healthy weight is important for heart health. Excess body weight, especially abdominal obesity, increases the risk of cardiovascular disease. Aim for a healthy body weight through a combination of a balanced diet and regular physical activity. Chronic stress can contribute to the development of cardiovascular disease. Implementing stress management techniques such as exercise, meditation, deep breathing exercises, and engaging in hobbies or activities you enjoy can help reduce stress levels and promote heart health. Regular visits to your healthcare provider are crucial for early detection and management of cardiovascular risk factors. Stay up to date with routine screenings, such as blood pressure checks, cholesterol levels, and diabetes screenings. Follow your healthcare provider's recommendations for managing any underlying health conditions. Remember that lifestyle changes should be personalized based on individual needs and in consultation with healthcare professionals [5,6].

Conclusion

Adopting a cardio protective lifestyle is a long-term commitment that can significantly improve heart health and reduce the risk of cardiomyopathy and other cardiovascular diseases. While progress has been made in understanding and mitigating doxorubicin-induced cardiomyopathy, further research is needed to develop effective preventive strategies and treatment approaches. Clinical trials and translational research studies continue to explore novel interventions and therapeutic options to protect the heart while maximizing the benefits of doxorubicin treatment.

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