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Eliza Mac*

Pharmaceutical particle technology is used to improve drug compounds' low dissolution rate in the gastrointestinal fluids following oral administration, which limits their bioavailability due to their poor aqueous solubility. The molecule innovation includes a few methodologies from the regular size decrease cycles to the more up to date, novel molecule innovations that change the dissolvability properties of the medications and produce strong, powdered type of the medications that are promptly solvent in water and can be effectively formed into different measurement structures. The solid particle technologies that can be used to improve the aqueous solubility, dissolution, and bioavailability of drugs are highlighted in this overview. Solubility, dissolution, and gastrointestinal permeability are fundamental parameters that control the rate and extent of drug absorption as well as its bioavailability, as has been well explained. A drug's water solubility is a fundamental property that is crucial to the drug's absorption after oral administration. In addition, it regulates whether a drug can be administered via parenteral route and is useful for manipulating and testing drug properties during the drug design and development process. While the dissolution rate at which the solid drug or drug from the dosage form enters solution is crucial when the dissolution time is limited, drug solubility is an equilibrium measure. Aqueous solubility and drug permeability are also important parameters attributed to oral bioavailability, despite the fact that a drug's oral bioavailability depends on its aqueous solubility, drug permeability, dissolution rate, first-pass metabolism, and susceptibility to efflux mechanisms. In recent years, there has been an increase in the number of insoluble drug candidates in drug discovery, with almost 70% of new drug candidates lacking water solubility. After oral administration, these drug candidates' bioavailability is limited by their poor aqueous solubility and dissolution in gastrointestinal fluids.


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