International Journal of Drug Research and Technology

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Yimin Cui

Department of Clinical Pharmacology, Peking University First Hospital, Beijing, China

Publications

  • Mini Review   
    COMBINING MICROTITRE TECHNOLOGY AND MICROFLUIDICS FOR FASTER DRUG DISCOVERY
    Author(s): Yimin Cui*

    Improved in vitro determinations of drug efficacy and cellular response to administered drugs will be possible by detecting multiple components from a single RBC sample using a flow-based system in less than 20 minutes. By incorporating multiple cell types into a single device, this is an example of an improved in vitro measurement involving iloprost, a drug that is said to increase blood flow. An 18-well microfluidic array that serves as a precursor to a 96-well micro titre plate device can be addressed by fluid flow using this method. The ability of the microfluidic array presented here to better mimic the in vivo circulation by incorporating the flow of blood components, as well as simultaneous detection and laboratory automation for micro titre plates, suggest that improved mechanistic drug research studies will be possible. The micro fluidic array can also be used to mea.. Read More»
    DOI: 10.37421/2277-1506.2022.11.366

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